Blood and Bone Marrow Pathology E-Book , livre ebook

Blood and Bone Marrow Pathology
Second Edition

Anna Porwit, MD, PhD
Professor, Department of Pathology, Karolinska University Hospital and Institute, Stockholm, Sweden
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

Jeffrey McCullough, MD
Professor of Laboratory Medicine and Pathology, American Red Cross Professor of Transfusion Medicine, University of Minnesota, Minneapolis, MN, USA

Wendy N. Erber, MD, DPhil, FRCPA, FRCPath
Consultant Hematologist, Addenbrooke’s Hospital; Hematology Department, University of Cambridge, Cambridge, UK
Churchill Livingstone
Front Matter

Blood and Bone Marrow Pathology
SECOND EDITION
Anna Porwit MD, PhD
Professor
Department of Pathology
Karolinska University Hospital and Institute
Stockholm, Sweden;
Department of Laboratory Medicine and Pathobiology
University of Toronto
Toronto, ON, Canada
Jeffrey McCullough MD
Professor of Laboratory Medicine and Pathology
American Red Cross Professor of Transfusion Medicine
University of Minnesota
Minneapolis, MN, USA
Wendy N. Erber MD, DPhil, FRCPA, FRCPath
Consultant Hematologist
Addenbrooke’s Hospital;
Hematology Department
University of Cambridge
Cambridge, UK
For additional online content visit expertconsult.com
Edinburgh London New York Oxford Philadelphia St Louis Sydney Toronto 2011
Commissioning Editor: Michael Houston
Development Editors: Ben Davie & Rachael Harrison
Editorial Assistant: Kirsten Lowson
Project Manager: Anita Somaroutu
Design: Kirsteen Wright
Illustration Manager: Bruce Hogarth
Illustrator: Robert Britton
Marketing Managers (UK/USA): Gaynor Jones & Cara Jespersen
Copyright

An Imprint of Elsevier Limited
© 2011, Elsevier Limited All rights reserved.
First edition 2002
Second edition 2011
The right of Anna Porwit, Jeffrey McCullough and Wendy N. Erber to be identified as authors of this work has been asserted by them in accordance with the Copyright, Designs and Patents Act 1988.
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions .
This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).


Notices
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
Churchill Livingstone
British Library Cataloguing in Publication Data
Blood and bone marrow pathology.
1. Blood – Diseases. 2. Bone marrow – Diseases. 3. Blood – Diseases – Histopathology. 4. Bone marrow – Diseases – Histopathology. I. Porwit, Anna. II. McCullough, Jeffrey J. III. Erber, Wendy N., 1957–
616.1′5 – dc22
ISBN-13: 9780702031472


Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
Preface
In the time since the first edition of Blood and Bone Marrow Pathology was published in 2002, major advances have been made in all facets of the field of hematology. Much of this has resulted from progress in molecular genetics which has enhanced our understanding of the pathological basis of hematological disorders. The knowledge of the molecular basis of hematological diseases is now being used to both diagnose and classify non-malignant and malignant hematological disorders. This has had a major impact on the hemopoietic tumors where the World Health Organization classification is in large part based on this new biological information. This second edition of Blood and Bone Marrow Pathology has therefore been significantly updated and revised to incorporate these advances. Many chapters have been totally rewritten to encapsulate the advances in the understanding of the fundamentals of the pathology of blood and bone marrow in health and disease. This book truly focuses on the pathology of blood and bone marrow. Although clinical aspects of disease are alluded to along with treatment approaches, this is only given as a guide to the reader. The book is aimed at bridging pure cytology and histology with clinical hematology diagnostics.
The book was originally to be co-edited by Professor Sunitha Wickramasinghe, co-editor of the first edition and a major driving force behind Blood and Bone Marrow Pathology . It is with immense sadness we note the untimely death of Sunitha during the production of this second edition. His death has been a tremendous loss to hematology.
The book is divided into sections on normal blood and bone marrow, pathology of the bone marrow, disorders of erythroid cells and leukocytes, abnormalities of hemostasis and immunohematology. Within each section there are chapters devoted to specific aspects of each of these areas and which have been written by internationally recognized experts. We are most grateful to them for their outstanding contributions and the time they have devoted to this project.
We are also immensely grateful to the publishers and especially Michael Houston, Ben Davie and Rachael Harrison for their enormous help in bringing this project to fruition. We hope this second edition of Blood and Bone Marrow Pathology will be of benefit to clinical and laboratory hematologists, hematopathologists and those in training in gaining a better understanding of the pathology of blood and bone marrow.

Anna Porwit

Jeffrey McCullough

Wendy N. Erber
2011
Contributors

Kenneth C. Anderson, MD, PhD, Director, Jerome Lipper Multiple Myeloma Center Dana-Farber Cancer Institute Kraft Family Professor of Medicine Harvard Medical School Boston, MA, USA

Daniel A. Arber, MD, Professor and Associate Chair of Pathology Department of Pathology Stanford University Stanford, CA, USA

Donald M. Arnold, MDCM, MSc, FRCPC, Assistant Professor, Department of Medicine Division of Hematology and Thromboembolism Michael G. DeGroote School of Medicine McMaster University Canadian Blood Services Hamilton, ON, Canada

Barbara J. Bain, MB BS, FRACP, FRCPath, Professor in Diagnostic Hematology Imperial College Honorary Consultant Hematologist Department of Hematology St Mary’s Hospital London, UK

Marie Christine Béné, Pharm Sci D, PhD, Professor of Immunology Immunology Laboratory Faculty of Medicine Nancy University and University Hospital Vandoeuvre-lès-Nancy, France

David H. Bevan, FRCP FRCPath, Director and Consultant Hematologist Centre for Hemostasis and Thrombosis Guy’s and St Thomas’ NHS Foundation Trust London, UK

Oliver Bock, MD, Professor for Transplantation Pathology Head Central Tissue and Specimen Bank Institute of Pathology Medizinische Hochschule Hannover Hannover, Germany

Jeremiah C. Boles, MD, Hematology/Oncology Fellow Division of Hematology/Oncology University of North Carolina at Chapel Hill Chapel Hill, NC, USA

Gerben Bouma, PhD, Research Associate Molecular Immunology Unit UCL Institute of Child Health London, UK

Scott D. Boyd, MD, PhD, Assistant Professor of Pathology Department of Pathology Stanford University Stanford, CA, USA

Shannon M. Buckley, PhD, Postdoctoral Research Fellow Department of Pathology New York University Medical Center New York, NY USA

Guntram Büsche, Lecturer in Hematopathology Institute of Pathology Medizinische Hochschule Hannover Hannover, Germany

Magdalena Czader, MD, PhD, Director, Division of Hematopathology Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis, IN, USA

Geoff Daniels, PhD, FRCPath, Head of Molecular Diagnostics and Senior Research Fellow Bristol In