Cancer of the Skin E-Book , livre ebook

CANCER of the SKIN
Second Edition

Darrell S. Rigel, MD
Clinical Professor of Dermatology, New York University Medical Center, New York, NY, USA

June K. Robinson, MD
Professor of Clinical Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

Merrick Ross, MD
Professor of Surgery, Chief, Melanoma Section, Department of Surgical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA

Robert J. Friedman, MD, MSc (Med)
Clinical Professor, Department of Dermatology, New York University School of Medicine, New York, NY, USA

Clay J. Cockerell, MD
Clinical Professor, Dermatology and Pathology
Director, Cockerell and Associates Dermpath Diagnostics
Director, Division of Dermatopathology, University of Texas Southwestern Medical Center, Dallas, TX, USA

Henry W. Lim, MD
Chairman and C. S. Livingood Chair, Department of Dermatology, Henry Ford Hospital, Senior Vice President for Academic Affairs, Henry Ford Health System, Detroit, MI, USA

Eggert Stockfleth, MD, PhD
Professor of Dermatology, Head of Skin Cancer Center Charité, Vice-chair of Department of Dermatology, Venereology and Allergy, Charité – University Medical Center Berlin, Berlin, Germany

John M. Kirkwood, MD
Usher Professor of Medicine, Dermatology, and Translational Science, University of Pittsburgh School of Medicine, Director, Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Saunders
Front matter
CANCER of the SKIN
Commissioning Editors: Claire Bonnett and Russell Gabbedy
Development Editor: Rachael Harrison
Project Manager: Jess Thompson
Design: Kirsteen Wright
Illustration Manager: Merlyn Harvey
Illustrator: Ethan Danielson
Marketing Manager: Gaynor Jones and Helena Mutak

CANCER of the SKIN
Second Edition
Darrell S. Rigel MD , Clinical Professor of Dermatology New York University Medical Center New York, NY, USA
June K. Robinson MD , Professor of Clinical Dermatology Feinberg School of Medicine Northwestern University Chicago, IL, USA
Merrick Ross MD , Professor of Surgery Chief, Melanoma Section Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston, TX, USA
Robert J. Friedman MD, MSc (Med) , Clinical Professor Department of Dermatology New York University School of Medicine New York, NY, USA
Clay J. Cockerell MD , Clinical Professor, Dermatology and Pathology; Director, Cockerell and Associates Dermpath Diagnostics; Director, Division of Dermatopathology University of Texas Southwestern Medical Center Dallas, TX, USA
Henry W. Lim MD , Chairman and C. S. Livingood Chair Department of Dermatology Henry Ford Hospital Senior Vice President for Academic Affairs Henry Ford Health System Detroit, MI, USA
Eggert Stockfleth MD, PhD , Professor of Dermatology Head of Skin Cancer Center Charité Vice-chair of Department of Dermatology, Venereology and Allergy Charité – University Medical Center Berlin Berlin, Germany
John M. Kirkwood MD , Usher Professor of Medicine, Dermatology, and Translational Science University of Pittsburgh School of Medicine Director, Melanoma and Skin Cancer Program University of Pittsburgh Cancer Institute Pittsburgh, PA, USA
For additional online content visit www.expertconsult.com

Additional video content can be found at expertconsult.com
Copyright

SAUNDERS an imprint of Elsevier Inc.
© 2011, Elsevier Inc. All rights reserved.
Harold S. Rabinovitz retains copyright of all figures and videos with the credit line: Courtesy of Harold S. Rabinovitz
Copyright of all figures and tables in Chapter 49: Surgical excision of melanoma is retained by Robert Andtbacka and The Huntsman Cancer Institute, University of Utah
First edition 2005
Second edition 2011
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions .
This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).
Chapter 41 : Curettage and Electrodesiccation is in the public domain.
The images within Chapter 14 : Paget’s Disease are in the public domain. Where images are credited to Harold S. Rabinovitz in Chapters 36 and 38 copyright is retained by the author.
Copyright of all figures and tables in Chapter 49: Surgical excision of melanoma is retained by Robert Andtbacka and The Huntsman Cancer Institute, University of Utah


Notices
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
ISBN: 978-1-4377-1788-4
Cancer of the skin. – 2nd ed.
1. Skin–Cancer.
I. Rigel, Darrell S.
616.9’9477-dc22
Library of Congress Cataloging in Publication Data
A catalog record for this book is available from the Library of Congress

Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
Foreword
It is now over two decades ago that several of the editors and myself (Robert J. Friedman, Darrell S. Rigel and Alfred W. Kopf) published the seminal comprehensive text entitled Cancer of the Skin . The current text is an update on the enormous progress that has been made on all levels, including clinical, therapeutic, epidemiologic, genetic and histopathologic, and on all levels of basic sciences with emphasis on neoplastic cellular biology.
Cancers of the skin in the United States of America have the highest incidence of malignancies of any organ system – and the incidence keeps rising inexorably. In addition to the over 2,000,000 non-melanoma skin cancers anticipated in 2010, it is expected there will be over 68,000 new invasive melanomas diagnosed and over 8700 deaths from melanomas. This translates to a lifetime risk for melanoma of 1 in 37 for men and 1 in 56 for women!
A broad array of cancers of the skin is included in this comprehensive work. Special emphasis is placed on those cutaneous cancers that are particularly prevalent (e.g. basal cell carcinoma) and those which are responsible for the highest number of fatalities (e.g. melanoma and squamous cell carcinoma).
In order to relay to the reader in the most vivid way, all of the clinical images are published in full color. Every attempt has been made to provide clinical and histologic images of the highest quality.
Major emphasis in this text is on the diagnosis and management of cutaneous malignancies so that the reader is provided with the most advanced diagnostic and therapeutic measures available to date for each type of skin cancer. Thus, the editors and authors have made every effort to provide not only the commonly used therapeutic approaches, but also those modalities considered on the ‘cutting edge’ of our present therapeutic armamentaria.
The backbone of Cancer of the Skin is the remarkable productivity of the many authors who have been selected by the editors because of their interest and recognition of the specific malignant neoplasm dealt with in each of the chapters. Their broad experience in cutaneous etiology and the therapeutic guidelines they have documented are valuable assets to any individual involved in the multi-disciplinary needs of these patients. Thus, Cancer of the Skin serves as a valuable resource not only to physicians but also to all others who deal with the consequences of malignant tumors of the skin.
It is our aspiration that you will find this comprehensive textbook a valuable summary of the current knowledge gleaned by the literally thousands of years of combined clinical and therapeutic experience coupled with extensive reviews of literature by the multiple authors who have so arduously presente